IR-001 Ingredient Research

Alpha-Ketoglutarate

A five-carbon Krebs-cycle intermediate, C₅H₆O₅, also called 2-oxoglutarate.

Established Biology

Why it matters

Alpha-ketoglutarate sits inside the Krebs cycle rather than upstream of NAD+. It is produced by one reaction that reduces NAD+ to NADH and consumed by another that does the same.

Key points

  • It is one of the eight intermediates of the Krebs cycle.
  • It interconverts with glutamate, linking energy and amino-acid metabolism.
  • It is a required co-substrate for the alpha-KG-dependent dioxygenase enzymes.
  • Its relationship to markers of biological aging is early and largely preclinical.
The full alpha-ketoglutarate page

References

  1. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-ketoglutarate: physiological functions and applications. Biomol Ther. 2016;24(1):1–8. doi:10.4062/biomolther.2015.078
  2. Martínez-Reyes I, Chandel NS. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 2020;11:102. doi:10.1038/s41467-019-13668-3

Related records

Library records describe established biology and published research. They do not describe an effect of any Natal Health product. These statements have not been evaluated by the Food and Drug Administration.

← Back to the Library