Pre-launchLaunching soon — we are not taking orders yet. You are welcome to explore the Library in the meantime.

The Natal Library · Science Collection

Age exceptionally.

AKG PLUS™ is a coordinated cellular vitality formula built around 1,360 mg of calcium alpha-ketoglutarate, with NAD⁺ precursors and complementary nutrients supporting normal NAD⁺ metabolism, everyday energy, and antioxidant defenses.*

60-day guarantee Made in USA · cGMP Third-party tested
Plate I — The Human Cell
10
Named ingredients
120
Capsules per bottle
30
Daily servings
1,360 mg
Ca-AKG per serving
Education Card 02

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of your body. It plays a critical role in the processes that keep you energized, resilient, and healthy.

As we age, NAD+ levels naturally decline. Supporting NAD+ is supporting you.

The Natal LibraryScience Collection SC-002

Energy production

Helps convert the food you eat into usable cellular energy.

Genomic maintenance

NAD⁺ is a required substrate for PARP enzymes, part of the cell's normal DNA-maintenance machinery.

Cellular protection

Helps defend cells against oxidative stress and environmental damage.

Cellular signalling

Sirtuins — a family of enzymes involved in metabolic regulation — depend on NAD⁺ to function.

Describes established biology. Does not describe an effect of this product.

The formulation question

Most NAD⁺ formulas focus on the precursor. We looked at the whole system.

It is a fair thing to notice. Our largest ingredient by weight — 1,360 mg of calcium alpha-ketoglutarate — is not an NAD⁺ precursor at all.

That is deliberate. NAD⁺ does not work alone in the cell, and a formula built around it should not either.

Established biology

Where α-KG sits

Inside your mitochondria, nutrients are processed through the Krebs cycle — eight steps that turn what you eat into usable cellular energy. Alpha-ketoglutarate is one of those eight steps.

Three times per turn of the cycle, NAD⁺ accepts electrons and becomes NADH.

A cell, with mitochondria surrounding the nucleus
The Krebs (TCA) cycle, showing where alpha-ketoglutarate sits A ring of eight metabolites connected clockwise by arrows. In order: citrate, isocitrate, alpha-ketoglutarate, succinyl-CoA, succinate, fumarate, malate and oxaloacetate, which returns to citrate. Three steps convert NAD+ to NADH. Two of the three sit either side of alpha-ketoglutarate: isocitrate to alpha-ketoglutarate, and alpha-ketoglutarate to succinyl-CoA. Both also release carbon dioxide. The third is malate to oxaloacetate. Succinate to fumarate converts FAD to FADH2, and succinyl-CoA to succinate converts GDP to GTP. The full step-by-step detail is in the numbered list below this diagram. aconitase isocitrate dehydrogenase α-ketoglutarate dehydrogenase succinyl-CoA synthetase succinate dehydrogenase fumarase malate dehydrogenase citrate synthase NAD⁺ → NADH + CO₂ NADH NAD⁺ → NADH + CO₂ NADH GDP → GTP FAD → FADH₂ NAD⁺ → NADH Acetyl-CoA Citrate 1 Isocitrate 2 α-Ketoglutarate α-KG Succinyl-CoA 4 Succinate 5 Fumarate 6 Malate 7 Oxaloacetate 8

The eight steps

Select a step for the reaction, the enzyme that catalyses it, and what happens to NAD⁺.

Two of those three conversions happen on either side of α-KG.

α-KG is produced by a reaction that reduces NAD⁺ to NADH, and consumed by another that does the same. It is not a precursor. It is a neighbour.

Diagram describes established biochemistry. It does not describe an effect of this product.

The architecture

Different roles. One cellular strategy.

NR + NMN NAD⁺ precursors
Ca-AKG Krebs-cycle intermediate
AKG PLUS™
NAC Cysteine for glutathione
Complementary nutrients Additional cellular pathways

Because NAD⁺ doesn't work alone. Neither should your formula.

NAD⁺ Activator is the product. AKG PLUS™ is how it is formulated.

Read the full α-KG science

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References
  1. Li et al. (2024). Alpha-ketoglutarate and cellular metabolism.
  2. Cheng D. & Liu J. (2022). 2-oxoglutarate in mitochondrial function.
  3. Cheng C., Hu D., Kang F. (2024). Alpha-ketoglutarate and markers of biological aging.

Carried from the “Why α-KG Matters” plate. Each entry needs its DOI link added before publication.

The Formula

Multiple ingredients. Distinct roles. One coordinated formula.

Your cells don't depend on just one system — and neither should your daily routine. Each ingredient earns its place by contributing a distinct role.

Specimen Plate · No. 1

NMN

100 mg
Supports NAD+ metabolism*

A direct precursor the body can use in NAD+ metabolism, supporting normal cellular energy production.*

Specimen Plate · No. 2

Nicotinamide Riboside

200 mg
Supports NAD+ metabolism*

A form of vitamin B3 that serves as a precursor to NAD+, supporting cellular energy.*

Specimen Plate · No. 3

Calcium AKG

1,360 mg
Supports cellular metabolism*

A naturally occurring compound involved in cellular metabolic pathways and normal energy-producing processes.*

Specimen Plate · No. 4

N-Acetyl Cysteine

200 mg
Supports antioxidant defenses*

Provides cysteine, which the body uses to produce glutathione — one of its most important natural antioxidants.*

Specimen Plate · No. 5

L-Arginine

200 mg
Supports healthy circulation*

An amino acid involved in nitric oxide production, supporting healthy circulation and normal vascular function.*

Specimen Plate · No. 6

Zinc

1.5 mg
Essential mineral support*

Supports normal immune function and contributes to hundreds of enzymatic reactions throughout the body.*

Specimen Plate · No. 7

Ziziphi Spinosae Semen Extract (5:1)

100 mg
Supports relaxation and restful balance*

An extract of jujube seeds, traditionally used to support calm and restful balance.*

Specimen Plate · No. 8

Proprietary Blend — 470 mg

Whey peptide, goji extract, sea cucumber peptide.

Goji extract

Goji extract

A berry extract rich in antioxidants and phytonutrients that support overall cellular health.*

Whey peptides

Whey peptides

Bioavailable milk-derived peptides that support muscle maintenance and everyday recovery.*

Sea cucumber peptides

Sea cucumber peptides

Marine-sourced peptides that support joint comfort, skin, and overall vitality.*

Cellular Vitality Formula
AKG PLUS™ · SC-001

Cellular Vitality Formula

NAD+ Activator · Cellular Vitality Formula

  • Supports normal NAD+ metabolism*
  • Supports cellular energy-producing pathways*
  • Supports antioxidant defenses*

Not yet available — we are not taking orders until launch.

  • 60-day guarantee
  • Third-party tested
  • Made in USA
  • Free US shipping
NAD+ Activator™️ - 90 Day Supply - (3 Bottles)

NAD+ Activator™️ - 90 Day Supply - (3 Bottles)

$149.97
NAD+ Activator — 90-Day Supply Three bottles. One decision, made once. NAD+ Activator is a daily formula built around calcium alpha-ketoglutarate — 1,360 mg per serving, declared on the label. α-KG...
The Natal Standard

Science should build confidence — not confusion.

We distinguish between established biology, emerging research, and marketing hype. Confidence begins with clarity.

Principle I

Thoughtful formulation

Every ingredient has a purpose. Nothing is included simply to make a label look impressive.

Principle II

Clear labels

Amounts, serving sizes, and sourcing are printed where you can read them. We would rather you check than take our word for it.

Principle III

Responsible science

Clear language over technical jargon, so you can make informed decisions with confidence.

The Living Library of Longevity

More life in the years ahead.

Healthy aging isn't about turning back the clock — it's about supporting the energy, resilience, and vitality to keep doing the things you love.

Start with AKG PLUS™
Common Questions

Before you begin

How do I take AKG PLUS™?

Take four capsules daily, preferably with food, or as directed by your healthcare professional. Each bottle contains 120 capsules — a full 30-day supply.

What if it isn't right for me?

Every order is covered by a hassle-free 60-day money-back guarantee. If you're not satisfied, contact us for a full refund — no lengthy forms, no hoops.

Where is it manufactured?

AKG PLUS™ is manufactured in the USA in a cGMP-certified facility and third-party tested.

Why ten ingredients instead of one?

Cellular vitality doesn't depend on a single pathway. Rather than relying on one ingredient, AKG PLUS™ combines nutritional precursors and complementary ingredients so the formula supports cellular health from several directions.*

Are there any allergens?

AKG PLUS™ contains milk (from whey peptides). Other ingredients: vegetable capsule, microcrystalline cellulose, magnesium stearate, and silicon dioxide.

Why four capsules?

Volume. A single serving delivers 1,360 mg of calcium alpha-ketoglutarate alone — more than most complete formulas weigh in total. Four capsules is what it takes to deliver the doses on the label without compressing them into something smaller and weaker.

How do I skip, pause, or cancel a subscription?

From your account, at any time — no phone call and no forms. Changes made before your next billing date apply to that order.

What is the difference between the 30-day and 90-day supply?

Quantity only. The formula is identical. The 90-day supply is three bottles, priced lower per bottle.

The Natal Library

New entries, as they are written.

Plain-language notes on cellular science, sent occasionally. No promotions and no urgency — this is the Library, not a mailing list.

One email at a time. Unsubscribe whenever you like.