MB-004 Molecular Biology

Sirtuins

A family of enzymes that remove chemical tags from proteins in reactions that consume NAD+.

Established Biology

Why it matters

Sirtuins are one of the clearest links between a cell's NAD+ supply and its regulatory machinery: they cannot work without NAD+ as a co-substrate.

Key points

  • Humans have seven sirtuins, located in different parts of the cell.
  • They remove acetyl and related groups from target proteins.
  • Each reaction consumes a molecule of NAD+.
  • Their relationship to aging is under active investigation and is not settled.

References

  1. Chang H-C, Guarente L. SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab. 2014;25(3):138–145. PMC3943707
  2. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22:119–141. doi:10.1038/s41580-020-00313-x

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